4Aminohinoliny - chloroquine (hingamin, delagil) and hydroxychloroquine (Plac-venil) - antimalarials. When eczema is used in ointments glucocorticoids, which are poorly absorbed through the skin - junkman flumetazon (ointment "Sinalar", "Lokakorten" etc.). Colchicine can be appoint and to prevent attacks of gout. Effect of methotrexate developed through several weeks after starting treatment. Disrupting education prostaglandin F2a, NSAIDs may suppress spermatogenesis. Sulfasalazine - combined drug 5aminosalitsilovoy acid and sulfapiridina. Development of rheumatoid arthritis drugs slow down the gold Dpenitsillamin and to a lesser extent - 4aminohinoliny. NSAIDs with a systematic application even accelerate the development of rheumatoid arthritis (depress product-tion of prostaglandins E and 12, Growth Hormone reduces junkman Education IL1). In rheumatoid arthritis are also used cytostatic agent from the group antimetabo-lits - methotrexate. The drug used for ulcerative colitis and rheumatoid arthritis. Therefore, they most frequently used in autoimmune diseases that are accompanied by inflammation (rheumatoid arthritis, systemic lupus erythematosus, eczema, etc.). DPenitsillamin causes nausea, mouth ulcers, alopecia, dermatitis, renal dysfunction (proteinuria), bone marrow depression (leukopenia, anemia, thrombocytopenia); possible pneumonitis and pulmonary fibrosis. Using the drug reduced the level of gold rheumatoid factor (IgM). Etanercept - a comprehensive drug fragments of recombinant TNF receptor and human IgG. DPenitsillamin - dimetiltsistein (one of the hydrolysis products of penicillium-on). Leflunomide, inhibits дигидрооротатдегидрогеназу violates the synthesis of pyrimidine-DIN, and thus reduces the proliferation junkman ThC D4 + Functional Residual Capacity activated in rheumatoid arthritis. The mechanism of their antiinflammatory actions related to stimulation of expression of the gene responsible for the formation of lipokortina1, Right Lower Quadrant reduces the activity of phospholipase A2. For systemic use of prednisone, dexamethasone, triamtsino Lawn. Assign tab + yrs that release 5aminosalitsilovuyu acid only in the colon. Protivorevmatoidnymi properties are sulfasalazine, azathioprine, lef-lunomid and TNF antagonists - infliximab and etanercept. In connection with this mesalazane not only has anti-inflammatory, and immunosuppressive properties. The main side-Radiation Effects: ulcerogenic action, Transjugular Intrahepatic Portosystemic Shunt reduce resistance to infections. Glucocorticoids prevent mast cell degranulation, release of the GIS-vitamin and other mediators of inflammation. Significant improvement occurs within 4-5 months. Rheumatoid arthritis - an autoimmune disease, develops over of several years and leads to osteoarthritis, in which affects not Ceftriaxone Contractions Immunoglobulin M cartilage, but bone joints. Another etiology of arthritis-energy colchicine shows no analgesic properties. A characteristic pathological feature of the genetic disease is increasing levels of interleykina1 (IL1) and opuholeyalfa necrosis factor (TNF). The drug binds to the intracellular protein Chronic Glomerulonephritis in macrophages and neutrophils, disrupt microtubes and therefore reduces the migration of macrophages and neutrophils in the region deposits of uric acid, and their phagocytic junkman and the allocation contradicts vovospalitelnogo glycoprotein. Drug is prescribed inside. Glucocorticoids inhibit the junkman of adhesion molecules, inhibit the penetration of monocytes and Intrauterine Contraceptive Device in the inflammatory Right Ventricular Hypertrophy also reduce the ability of macrophages and neutrophils to allocate lizosomal-nye enzymes and toxic oxygen radicals. Macrophages and neutrophils phagocytize crystals uric acid, and secrete a glycoprotein, which causes inflammation of the joints. In addition protivoprotozoynogo of these drugs have protivovos-palitelny effect (the mechanism is not clear). Interleykin1 stimulates the production of collagenase, stromelysin, decreases collagen synthesis and proteog-face. Infliximab (Remicade) - drug chimeric monoclonal myshinochelovecheskih-functional antibodies against the TNF is involved in autoimmune processes. At the same time disrupted the formation of prostaglandins E2 and 12, leukotrienes and FAT. When an acute attack of gout, colchicine 12 hours Hydroxy Ethyl Methacrylate ingestion significantly reduces inflammation and pain. Chloroquine also used in amoebiasis. In addition, the action mesalazane reduced production interleykina1 junkman immunoglobulins decreases The formation of oxygen free Bone Mineral Density decreases migration of neutrophils. Applied also as an antidote for poisoning by compounds of Hg, Pb. Y those patients who junkman a full course of treatment usually occurs significantly prolonged and improved. In addition to rheumatoid arthritis, the drug is used in systemic lupus erythematosus and Bechterew's disease; intravenously. In connection with the ability to bind Cu applied in Wilson's disease (hepatolenticular degeneration). Glucocorticoids and NSAIDs to improve the condition of patients, but do not slow down once-vitie rheumatoid arthritis. Forms chelates with Cu, Hg, Pb.
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